BDBM50360301 CHEMBL1933288::US9150577, 93

SMILES C[C@@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C

InChI Key InChIKey=ZHMXXVNQAFCXKK-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50360301   

TargetRibosomal protein S6 kinase alpha-2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 1.10nMpH: 7.5Assay Description:Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2016
Entry Details
Go to US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RSK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 139nMAssay Description:Inhibition of human PRKD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 20nMAssay Description:Inhibition of human RSK2-mediated CREB phosphorylation in HLR-CREB cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 16nMAssay Description:Inhibition of human LRRK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 35nMAssay Description:Inhibition of human PRKD1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase D3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 219nMAssay Description:Inhibition of human PRKD3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 161nMAssay Description:Inhibition of human RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 512nMAssay Description:Inhibition of human CLK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 112nMAssay Description:Inhibition of human CLK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 320nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 956nMAssay Description:Inhibition of human PDGFRaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 714nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50360301(CHEMBL1933288 | US9150577, 93)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RSK2 in MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed