BDBM50359499 (S)Methamphetamine::METHAMPHETAMINE

SMILES C[C@@H](Cc1ccccc1)NC

InChI Key InChIKey=MYWUZJCMWCOHBA-UHFFFAOYSA-N

Data  6 KI  1 IC50  12 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50359499   

TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  133nMAssay Description:Activation of rat wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rhesus macaque)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  5.30E+3nMAssay Description:Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  890nMAssay Description:Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  920nMAssay Description:Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  70nMAssay Description:Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of cAMP after 15 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human TAAR1 expressed in human HEK293T cells assessed as cAMP accumulation after 10 mins by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  279nMAssay Description:Activation of mouse wild type TAAR1 expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr by chemiluminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  2.04E+3nMAssay Description:Activation of rat TAAR1 transmembrane domain 6 Met268(6.55)Thr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  1.82E+3nMAssay Description:Activation of mouse TAAR1 transmembrane domain 7 Tyr287(7.39)Asn mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Mouse)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  18nMAssay Description:Activation of mouse TAAR1 transmembrane domain 6 Thr268(6.55)Met mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSolute carrier family 22 member 3(Rat)
Medical College of Georgia

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataIC50: 2.48E+5nMAssay Description:TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in OCT3-expressing HRPE cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2020
Entry Details Article
PubMed
TargetTrace amine-associated receptor 1(Rat)
Oregon Health & Science University

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataEC50:  202nMAssay Description:Activation of rat TAAR1 transmembrane domain 7 Asn287(7.39)Tyr mutant expressed in HEK293 cells assessed as stimulation of cAMP production after 1 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataKi:  2.46E+3nMAssay Description:Inhibition of VMAT2-mediated [3H]DA uptake in rat brain synaptic vesicles by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataKi:  2.46E+3nMAssay Description:Inhibition of VMAT2-mediated [3H]-dopamine uptake in rat striata isolated synaptic vesicles by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataKi:  8.32E+3nMAssay Description:Binding affinity towards sigma opioid receptor in guinea pig cerebral homogenate using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetSynaptic vesicular amine transporter(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataKi:  8.01E+4nMAssay Description:Displacement of [3H]DTBZ from VMAT2 in rat whole brain by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Bovine)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataKi:  5.50E+5nMAssay Description:In vitro inhibition of bovine monoamine oxidase B.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Rat)
Syntex Research

Curated by ChEMBL
LigandPNGBDBM50359499(METHAMPHETAMINE | (S)Methamphetamine)
Affinity DataKi:  2.70E+5nMAssay Description:Competitive inhibition of Rat liver Monoamine Oxidase B at 37 degree C (pH= 7.4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed