BDBM50359396 CHEMBL1929420::US8999994, 5

SMILES CN(CC#C)Cc1cc2cc(OCCC3CCN(Cc4ccccc4)CC3)ccc2n1C

InChI Key InChIKey=MDLQDZAGZXYYJT-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50359396   

TargetAcetylcholinesterase(Electric eel)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50: 420nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetCarboxylic ester hydrolase(Horse)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50: 2.10E+3nMpH: 8.0Assay Description:The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an elect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] A(Rat)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50: 6.70E+3nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of monoamine oxidases A and B was assessed by the Fowler and Tipton radiometric method (Biochem Pharmacol 1981, 30, 3329) usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Rat)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50: 1.30E+5nMpH: 7.4 T: 2°CAssay Description:The inhibitory activity of monoamine oxidases A and B was assessed by the Fowler and Tipton radiometric method (Biochem Pharmacol 1981, 30, 3329) usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2015
Entry Details
Go to US Patent

TargetAmine oxidase [flavin-containing] B(Rat)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50: 130nMAssay Description:Inhibition of rat liver mitochondrial MAO-B using [14C]-phenylethylamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] A(Rat)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of rat liver mitochondrial MAO-A using [14C]-5-hydroxytryptamine after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCholinesterase(Horse)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of equine serum BuchE using butyrylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Electric eel)
Consejo Superior De Investigaciones Cientificas

US Patent
LigandPNGBDBM50359396(CHEMBL1929420 | US8999994, 5)
Affinity DataIC50: 420nMAssay Description:Inhibition of Electrophorus electricus AchE using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed