BDBM50359202 CHEMBL1921816

SMILES CN1CC(C)(N=C(N)C1=O)c1cccc(NC(=O)c2ccc(Cl)cn2)c1

InChI Key InChIKey=ARWLTZWIOYRTKV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50359202   

TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359202(CHEMBL1921816)
Affinity DataIC50: 550nMAssay Description:Inhibition of human recombinant BACE1 using fluorescent Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH peptide as substrate after 1 hr by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359202(CHEMBL1921816)
Affinity DataIC50: 115nMAssay Description:Inhibition of human BACE1-mediated amyloid beta 42 secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359202(CHEMBL1921816)
Affinity DataIC50: 107nMAssay Description:Inhibition of human BACE1-mediated amyloid beta TOT secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed