BDBM50359198 CHEMBL1923160

SMILES C[C@]1(C(=O)N(CC(=N1)N)C)c2cccc(c2)NC(=O)c3ccc(cn3)Cl

InChI Key InChIKey=MRYFMHAPTQCQLE-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50359198   

TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359198(CHEMBL1923160)
Affinity DataIC50: 37nMAssay Description:Inhibition of human BACE1-mediated amyloid beta TOT secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359198(CHEMBL1923160)
Affinity DataIC50: 36nMAssay Description:Inhibition of human BACE1-mediated amyloid beta 42 secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359198(CHEMBL1923160)
Affinity DataIC50: 324nMAssay Description:Inhibition of human recombinant BACE1 using fluorescent Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH peptide as substrate after 1 hr by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed