BDBM50359197 CHEMBL1923159

SMILES CN1CC(N)=N[C@](C)(C1=O)c1cccc(NC(=O)c2ccc(Cl)cn2)c1

InChI Key InChIKey=MRYFMHAPTQCQLE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50359197   

TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359197(CHEMBL1923159)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BACE1-mediated amyloid beta TOT secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359197(CHEMBL1923159)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BACE1-mediated amyloid beta 42 secretion in human SKNBE2 cells expressing human APP695 after 18 hrs by sandwich alphalisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Research Informatics & Integrative Genomics

Curated by ChEMBL
LigandPNGBDBM50359197(CHEMBL1923159)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant BACE1 using fluorescent Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(Dnp)-OH peptide as substrate after 1 hr by spectr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed