BDBM50358942 CHEMBL1923750

SMILES COc1ccc2nc([nH]c2c1)-c1cccc(c1)-c1nc2ccccn2c1NC(C)(C)C

InChI Key InChIKey=ISCVINRUZPXLTR-UHFFFAOYSA-N

Data  2 KI  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50358942   

TargetBeta-secretase 1(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358942(CHEMBL1923750)
Affinity DataIC50: 178nMAssay Description:Inhibition of BACE1 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358942(CHEMBL1923750)
Affinity DataIC50: 4.12E+3nMAssay Description:Inhibition of BACE2 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358942(CHEMBL1923750)
Affinity DataEC50:  310nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP Swedish K595N and M596L double mutant assessed as inhibition of amyloid beta (1 to 40) productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358942(CHEMBL1923750)
Affinity DataEC50:  310nMAssay Description:Inhibition of BACE1 in human H4 cells expressing APP Swedish K595N and M596L double mutant assessed as inhibition of amyloid beta (1 to 42) productio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358942(CHEMBL1923750)
Affinity DataKi:  253nMAssay Description:Inhibition of BACE1 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by Michaelis-Menten equationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50358942(CHEMBL1923750)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of BACE2 expressing APP Swedish mutant using rhodamine-labeled EVNLDAEFK-quencher as substrate after 60 mins by Michaelis-Menten equationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed