BDBM50358480 CHEMBL1922132::US20240246972, Comparator 6

SMILES COc1cccc(CNC(=O)c2c[nH]c3nc(ccc23)-c2cn[nH]c2)c1

InChI Key InChIKey=YOXPJLZIOXCBGO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50358480   

TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 2nMAssay Description:Inhibition of human 6-His-tagged ROCK2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 11nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 2nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 11nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 10.2nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 0.960nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
Go to US Patent

TargetcAMP-dependent protein kinase catalytic subunit PRKX(Human)
Avicenna Biosciences, Inc.

US Patent
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 165nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
Go to US Patent

TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Avicenna Biosciences, Inc.

US Patent
LigandPNGBDBM50358480(CHEMBL1922132 | US20240246972, Comparator 6)
Affinity DataIC50: 46.2nMAssay Description:Compounds as a powder were dissolved in dimethyl sulfoxide to make a 10 mM stock. Compounds were tested in 10-dose IC50 triplicate mode with a 3-fold...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2024
Entry Details
Go to US Patent