BDBM50358204 CHEMBL1922094

SMILES Cc1c(sc2c1nc(nc2N3CCOCC3)c4cnc(nc4)N)CN5CCN(CC5)C(=O)[C@H](C)O

InChI Key InChIKey=YOVVNQKCSKSHKT-UHFFFAOYSA-N

Data  3 KI  19 IC50  9 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50358204   

LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 36nMAssay Description:Inhibition of PIK3 gamma-mediated Akt phosphorylation at Ser473 in human PC3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 7nMAssay Description:Inhibition of P13Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 14nMAssay Description:Inhibition of P13Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 27nMAssay Description:Inhibition of P13Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 5nMAssay Description:Inhibition of P13Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 5nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 40 mins by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  0.620nMAssay Description:Binding affinity to human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  250nMAssay Description:Binding affinity to human VPS34 (S282 to H879 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human PI4KCbeta (M1 to M828 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human mTOR (L1382 to W2549 residues) expressed in mammalian expression system at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  9.80E+3nMAssay Description:Binding affinity to DNAPK (unknown origin) by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  580nMAssay Description:Binding affinity to human PI3KC2beta (M1 to L1634 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  2.60nMAssay Description:Binding affinity to human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKd:  3.80nMAssay Description:Binding affinity to human PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system by Kinomescan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2019
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI4KbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI4KalphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase catalytic subunit type 3(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of VPS34 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 794nMAssay Description:Inhibition of PIKKC2beta by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of PI3K subunit p110delta assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 27nMAssay Description:Inhibition of PI3K subunit p110beta assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polari...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of PI3K subunit p110alpha assessed as formation of phosphatidylinositide-3-phosphate product formation after 30 mins by fluorescence polar...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of PIKKC2alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 134nMAssay Description:Inhibition of SykMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 232nMAssay Description:Inhibition of Mlk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 697nMAssay Description:Inhibition of FgrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 36nMAssay Description:Inhibition of PIK3 gamma-mediated Akt phosphorylation at Ser473 in human PC3 cells by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataIC50: 17nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant PI3Kalpha (unknown origin) using dioctanoylglycerol-PIP2 as substrate incubated for 30 mins in presence of TAMRA-PIP3 by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant mTOR expressed in insect cells assessed as phosphorylation of recombinant (GFP)-4-EBP1 measured after 30 mins by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Basel

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)
Affinity DataKi:  17nMAssay Description:Inhibition of human recombinant mTOR (1360 to 2549 residues) expressed in insect cells assessed as inhibition of GFP-labeled 4-EBP1 phosphorylation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2017
Entry Details Article
PubMed