BDBM50357873 CHEMBL1916133

SMILES COc1cc(F)c2nc(C)c3c(C)nc(-c4cnccc4C)n3c2c1

InChI Key InChIKey=WLBFHVBWNVZOKE-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50357873   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357873(CHEMBL1916133)Copy SMILESCopy InChI

Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
Copy BDB DOIPubMed
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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357873(CHEMBL1916133)Copy SMILESCopy InChI

Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL