BDBM50357831 CHEMBL1916090

SMILES COc1ccc2nc(C)c3c(C)nc(-c4cccnc4C)n3c2n1

InChI Key InChIKey=KKGNLHFXELBTHO-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50357831   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357831(CHEMBL1916090)Copy SMILESCopy InChI

Affinity DataIC50: 4.20nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50357831(CHEMBL1916090)Copy SMILESCopy InChI

Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/21/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL