BDBM50357825 CHEMBL1915891
SMILES COc1ccc2nc(C)c3c(C)nc(-c4cc(Cl)ccc4Cl)n3c2n1
InChI Key InChIKey=RMKFHXBPLKSLMZ-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50357825
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE5A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE11A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMAssay Description:Inhibition of N-terminal His-tagged human PDE10A expressed in Escherichia coli using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE3A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE4A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant bovine PDE6A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 332nMAssay Description:Inhibition of recombinant human PDE7A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human PDE2A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE9A using [3H]cGMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Human)
Pfizer
Curated by ChEMBL
Pfizer
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE1B using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair