BDBM50357764 CHEMBL1916399

SMILES OC(=O)CCC(=O)N1CCc2cc(ccc12)-c1noc(n1)-c1cc(OC(F)(F)F)cc(c1)C#N

InChI Key InChIKey=ASJOLIPQCOYRPT-UHFFFAOYSA-N

Data  6 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50357764   

TargetSphingosine 1-phosphate receptor 1(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human S1P1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 hr by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Mouse)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataEC50:  1.10nMAssay Description:Agonist activity at mouse S1P1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 hr by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Rat)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataEC50:  1nMAssay Description:Agonist activity at rat S1P1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 hr by HTRF ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataEC50:  31nMAssay Description:Agonist activity at recombinant human S1P1 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at recombinant human S1P2 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at recombinant human S1P3 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 4(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataEC50:  1.33E+3nMAssay Description:Agonist activity at recombinant human S1P4 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataEC50:  109nMAssay Description:Agonist activity at recombinant human S1P5 receptor expressed in HEK293 cells after 2 hrs by beta-arrestin assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50357764(CHEMBL1916399)
Affinity DataIC50: 1.00E+5nMAssay Description:Displacement of [3H]astemizole from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed