BDBM50357701 CHEMBL1915725::US9138494, Janssen B-3

SMILES Cc1cnc(COc2ccc(cc2)-c2nn(CCF)cc2-c2ccncc2)c(C)c1

InChI Key InChIKey=OWEZURWNYQWWNB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50357701   

LigandPNGBDBM50357701(CHEMBL1915725 | US9138494, Janssen B-3)
Affinity DataIC50: 0.980nMAssay Description:The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2016
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50357701(CHEMBL1915725 | US9138494, Janssen B-3)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human DATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50357701(CHEMBL1915725 | US9138494, Janssen B-3)
Affinity DataIC50: 1.58nMAssay Description:Inhibition of rat recombinant PDE10A expressed in baculovirus infected insect Sf9 cells using [3H]cAMP as substrate after 60 mins by scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50357701(CHEMBL1915725 | US9138494, Janssen B-3)
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE10A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed