BDBM50357427 CHEMBL1917511

SMILES CC(C)(C)c1cc(C(=O)Nc2nc(CN)cs2)n(Cc2ccccc2)n1

InChI Key InChIKey=XCKWZWHQTKSVSW-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50357427   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50357427(CHEMBL1917511)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human ERG expressed in Chinese hamster CHL cells by perforated patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50357427(CHEMBL1917511)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of CYP1A2-mediated phencetin o-de-ethylation in human liver microsomes by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50357427(CHEMBL1917511)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9-mediated Tolbutamide methlyhydroxylation in human liver microsomes by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50357427(CHEMBL1917511)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation in human liver microsomes by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50357427(CHEMBL1917511)
Affinity DataIC50: 400nMAssay Description:Inhibition of CYP2D6-mediated dextromethorphan O-demethylation in human liver microsomes by LCMS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed