BDBM50357339 CHEMBL1916897

SMILES CN(C)C\C=C\C(=O)N(C)c1cc2c(cc1Cl)nc(Nc1cc(F)ccc1C)c1cncn21

InChI Key InChIKey=HTKJLSGFOXVZRI-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50357339   

TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 3.98nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 3.39E+3nMAssay Description:Inhibition of LYN-A expressed in Sf9 cells after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAryl hydrocarbon receptor(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at Ah receptor in genetically engineered mouse cells expressing firefly luciferase gene by CALUX transactivational assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition cSRC expressed in Sf9 cells after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human full-length BTK expressed in Sf9 cells using FAM-Srctide peptide as substrate preincubated for 60 mins measured after 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of LYN-A expressed in Sf9 cells preincubated for 60 mins measured after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 2.79E+3nMAssay Description:Inhibition of C-terminal His6-tagged human full-length LCK expressed in Sf9 cells preincubated for 60 mins measured after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 410nMAssay Description:Inhibition cSRC expressed in Sf9 cells preincubated for 60 mins measured after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 3.35nMAssay Description:Inhibition of EGFR preincubated for 60 mins measured after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50357339(CHEMBL1916897)
Affinity DataIC50: 68nMAssay Description:Inhibition of EGFR after 60 mins by TR-FRET AssayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed