BDBM50356887 CHEMBL1915347

SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=O)c1nc2cc(F)c(F)cc2[nH]1

InChI Key InChIKey=KWTJQJSBJGKFFU-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50356887   

TargetHistamine H4 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356887(CHEMBL1915347)
Affinity DataKi:  53nMAssay Description:Antagonist activity at full length human H4R expressed in HEK293 cells assessed as reversal of forskolin-induced cAMP production by CRE-beta-lactamas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356887(CHEMBL1915347)
Affinity DataKi:  128nMAssay Description:Displacement of [3H]-histamine from full length human H4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356887(CHEMBL1915347)
Affinity DataKi:  128nMAssay Description:Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356887(CHEMBL1915347)
Affinity DataKi:  236nMAssay Description:Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356887(CHEMBL1915347)
Affinity DataKi:  1.79E+4nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed