BDBM50353855 CHEMBL1831166::US9604926, Compound CM-361::US9724435, Compound CM-361

SMILES COc1cc2CCN(CCCCn3cc(-c4ccc(F)cc4)c4ccccc34)Cc2cc1OC

InChI Key InChIKey=SAUWBVJOXSKPQX-UHFFFAOYSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50353855   

TargetSigma intracellular receptor 2(Rat)
The University of Mississippi

US Patent
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  4.37nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  4.37nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  295nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  544nMAssay Description:Displacement of [3H]YM-09151-2 from human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  870nMAssay Description:Displacement of [3H]YM-09151-2 from human D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  1.27E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT2A receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  1.35E+3nMAssay Description:Displacement of [125I]RTI-55 from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  1.51E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  2.95E+3nMAssay Description:Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat brain membrane after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  4.71E+3nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  4.71E+3nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetSodium-dependent dopamine transporter(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi:  5.00E+3nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353855(CHEMBL1831166 | US9604926, Compound CM-361 | US972...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]SCH-23390 from human D1 receptor in cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed