BDBM50353845 CHEMBL1830149::US9604926, Compound CM-341::US9724435, Compound CM-341

SMILES C(CCn1ccc2ccccc12)CN1CCN(CC1)C1CCCCC1

InChI Key InChIKey=QTVZKXTYXRRYBK-UHFFFAOYSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50353845   

TargetATP-dependent translocase ABCB1(Human)
University of Bari Aldo Moro

Curated by ChEMBL
LigandPNGBDBM50353845(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Affinity DataEC50:  460nMAssay Description:Inhibition of human MDR1 expressed in MDCK-MDR1 cells assessed as calcein cell accumulation after 30 mins by spectrofluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
The University of Mississippi

US Patent
LigandPNGBDBM50353845(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Affinity DataKi:  1.90nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50353845(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Affinity DataKi:  1.90nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353845(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Affinity DataKi:  3.28nMAssay Description:Displacement of (-)-[3H]pentazocine from sigma 1 receptor in rat brain membrane after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
The University of Mississippi

Curated by ChEMBL
LigandPNGBDBM50353845(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Affinity DataKi:  3.28nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Mouse)
The University of Mississippi

US Patent
LigandPNGBDBM50353845(CHEMBL1830149 | US9604926, Compound CM-341 | US972...)
Affinity DataKi:  3.28nMAssay Description:Compounds were evaluated for σ-1 and σ-2 binding in rat brain homogenates. Twelve concentrations of each test ligand (0.001-1,000 nM) were ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2019
Entry Details
Go to US Patent