BDBM50353389 CHEMBL1829764

SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(F)cc1F

InChI Key InChIKey=OTARHPTVFRBZQX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50353389   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50353389(CHEMBL1829764)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human 11 beta-HSD1 expressed in CHO cells assessed as conversion of [3H]cortisone to [3H]cortisol after 1 hr by scintillation proximity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50353389(CHEMBL1829764)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of 11 beta-HSD1 in differentiated human adipocytes assessed as conversion of [3H]-cortisone to [3H]-cortisol after 10 mins by HPLCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50353389(CHEMBL1829764)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human CYP3A4 assessed as rate of [14C]-formaldehyde/formic acid production by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50353389(CHEMBL1829764)
Affinity DataIC50: 18nMAssay Description:Inhibition of human 11 beta-HSD1 expressed in CHO cells assessed as conversion of [3H]-cortisone to [3H]-cortisol after 1 hr by scintillation proximi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed