BDBM50353127 CHEMBL1829301

SMILES COc1cc2c(NC3CCN(CC3)C(C)C)nc(nc2cc1OCCCN1CCCC1)N1CCCCCC1

InChI Key InChIKey=VJMBYBQPXIEJEM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50353127   

TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50353127(CHEMBL1829301)
Affinity DataIC50: 100nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 after 48 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50353127(CHEMBL1829301)
Affinity DataIC50: 20nMAssay Description:Inhibition of G9a assessed as hydrolysis of S-adenosyl-L-homocysteine after 2 mins by SAHH-coupled fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EHMT2(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50353127(CHEMBL1829301)
Affinity DataIC50: 100nMAssay Description:Inhibition of lysine methyltransferase G9a in human MDA-MB-231 cells assessed as reduction of H3K9me2 cellular level by immunofluorescence in-cell We...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed