BDBM50352722 CHEMBL1823218::US8835436, Example 142

SMILES Cc1c(nc(-c2ccccc2)n1-c1ccc(F)cc1)C(=O)NC[C@H](O)CN1CCN(CC1)c1cccc(Cl)c1C

InChI Key InChIKey=NVCPMQGMUOQYGP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50352722   

Target5-hydroxytryptamine receptor 2A(Human)
Green Cross

US Patent
LigandPNGBDBM50352722(CHEMBL1823218 | US8835436, Example 142)
Affinity DataIC50: 20.1nMpH: 7.4Assay Description:For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2C(Human)
Green Cross

US Patent
LigandPNGBDBM50352722(CHEMBL1823218 | US8835436, Example 142)
Affinity DataIC50: 534nMpH: 7.4Assay Description:For serotonin 5-HT2A binding, an aliquot of human recombinant serotonin 5-HT2A receptor (PerkinElmer Life and Analytical Sciences, USA) expressed in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
Go to US Patent

TargetSodium-dependent serotonin transporter(Human)
Green Cross

US Patent
LigandPNGBDBM50352722(CHEMBL1823218 | US8835436, Example 142)
Affinity DataIC50: 232nMpH: 7.4Assay Description:For serotonin transporter binding assays, a reaction mixture with a final volume of 0.25 ml was prepared by mixing a test compound, human serotonin t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2015
Entry Details
Go to US Patent

Target5-hydroxytryptamine receptor 2A(Human)
Green Cross

US Patent
LigandPNGBDBM50352722(CHEMBL1823218 | US8835436, Example 142)
Affinity DataIC50: 20.1nMAssay Description:Displacement of [3H]ketanserin from human recombinant serotonin 5-HT2A receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Green Cross

US Patent
LigandPNGBDBM50352722(CHEMBL1823218 | US8835436, Example 142)
Affinity DataIC50: 534nMAssay Description:Displacement of [3H]mesulergine from human recombinant 5-HT2C receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Green Cross

US Patent
LigandPNGBDBM50352722(CHEMBL1823218 | US8835436, Example 142)
Affinity DataIC50: 232nMAssay Description:Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed