BDBM50350248 CHEMBL1812545

SMILES Fc1ccc2c(C=Cc3nnn[nH]3)c[nH]c2c1

InChI Key InChIKey=JDBSZVDIUIRSDG-UHFFFAOYSA-N

Data  4 KI  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50350248   

TargetTryptophan 2,3-dioxygenase(Mouse)
Colorado College

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 1.96E+3nMAssay Description:Inhibition of mouse TDOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 1.74E+3nMAssay Description:Inhibition of human TDO2 expressed in mouse P815B cells assessed as kynurenine concentration formation using L-tryptophan as substrate incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptopha...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli BL21 using L-Trp as substrate incubated for 30 mins by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 620nMAssay Description:Inhibition of human recombinant pEF6/V5-His-tagged TDO2 transfected in HEK293-EBNA cells using L-tryptophan as substrate by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 1.87E+4nMAssay Description:Inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 398nMAssay Description:Inhibition of TDO (unknown origin) expressed in HEK293 cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 671nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of human TDO transfected in mouse P815B clone 19 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Mouse)
Colorado College

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of mouse TDO in P815 clone 12 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Ludwig Center For Cancer Research of The University of Lausanne

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human IDO1 transfected in mouse P815B clone-6 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Ludwig Center For Cancer Research of The University of Lausanne

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse IDO1 in P815 clone 6 cells by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Mouse)
Colorado College

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of mouse TDO expressed in mouse P815B cells assessed as inhibition of tryptophan catabolism by measuring kynurenine production after 8 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
Ludwig Center For Cancer Research of The University of Lausanne

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of mouse IDO1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataIC50: 620nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2016
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.50E+3nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.60E+3nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli using L-Trp as substrate after 10 to 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  5.60E+3nMAssay Description:Competitive inhibition of human recombinant TDO expressed in Escherichia coli BL21 using L-tryptophan as substrate by measuring conversion of N-formy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2013
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Xihua University

Curated by ChEMBL
LigandPNGBDBM50350248(CHEMBL1812545)
Affinity DataKi:  7.47E+3nMAssay Description:Uncompetitive inhibition of recombinant full length C-terminal His-tagged human TDO expressed in Escherichia coli using L-Trp as substrate after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed