BDBM50349634 CHEMBL1808992

SMILES CN1C2CCC1CC(C2)Oc1nc(nc(n1)-c1ccc(NC(=O)Nc2ccc(cc2)C(N)=O)cc1)N1CCOCC1

InChI Key InChIKey=LAOASXUCQVXLAY-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50349634   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50349634(CHEMBL1808992)Copy SMILESCopy InChI

Affinity DataIC50: 3.20nMAssay Description:Inhibition of human PI3Kalpha expressed in SF9 insect cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50349634(CHEMBL1808992)Copy SMILESCopy InChI

Affinity DataIC50: 72.5nMAssay Description:Inhibition of human PI3Kgamma expressed in SF9 insect cells after 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetSerine/threonine-protein kinase mTOR(Human)
Pfizer

Curated by ChEMBL

LigandBDBM50349634(CHEMBL1808992)Copy SMILESCopy InChI

Affinity DataIC50: 5.30nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/23/2012
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL