BDBM50348414 CHEMBL1800984

SMILES CC(C)([C@H]1c2ccccc2Oc2cc(O)ccc12)C(=O)Nc1nccs1

InChI Key InChIKey=WFESRNFSHAPECN-UHFFFAOYSA-N

Data  4 KI  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50348414   

TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataEC50:  60.1nMAssay Description:Transactivation activity of glucocorticoid receptor ligand binding domain expressed in human NP-1 Hela cells co-expressing GAL4 DNA binding domain by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataEC50:  27.1nMAssay Description:Transactivation activity at glucocorticoid receptor in human 13D3/Huh7 cells assessed as induction of tyrosine aminotransferase activity after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataEC50:  17.5nMAssay Description:Transrepression activity of glucocorticoid receptor in human A549 cells expressing AP-1 assessed as inhibition of PMA-induced AP-1 activity by lucife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataEC50:  9.30nMAssay Description:Transrepression activity of glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at mineralocorticoid receptor in human A549 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataKi:  0.300nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataKi:  22nMAssay Description:Binding affinity to progesterone receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataKi:  2.30E+3nMAssay Description:Binding affinity to ERalpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataKi:  2.34E+3nMAssay Description:Binding affinity to androgen receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed