BDBM50348408 CHEMBL1801005

SMILES CC(C)([C@@H](c1ccccc1)c1ccc(O)c(c1)C#N)C(=O)Nc1nccs1

InChI Key InChIKey=FDXWONUERKJVPB-UHFFFAOYSA-N

Data  3 KI  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50348408   

TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348408(CHEMBL1801005)
Affinity DataEC50: >1.00E+4nMAssay Description:Transactivation activity of glucocorticoid receptor ligand binding domain expressed in human NP-1 Hela cells co-expressing GAL4 DNA binding domain by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348408(CHEMBL1801005)
Affinity DataEC50: >5.00E+3nMAssay Description:Transactivation activity at glucocorticoid receptor in human 13D3/Huh7 cells assessed as induction of tyrosine aminotransferase activity after 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348408(CHEMBL1801005)
Affinity DataEC50:  506nMAssay Description:Transrepression activity of glucocorticoid receptor in human A549 cells expressing AP-1 assessed as inhibition of PMA-induced AP-1 activity by lucife...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348408(CHEMBL1801005)
Affinity DataEC50:  206nMAssay Description:Transrepression activity of glucocorticoid receptor in human A549 cells assessed as inhibition of IL1beta-stimulated NFkappaB-dependent E-selectin tr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348408(CHEMBL1801005)
Affinity DataKi:  0.900nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348408(CHEMBL1801005)
Affinity DataKi:  144nMAssay Description:Binding affinity to progesterone receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348408(CHEMBL1801005)
Affinity DataKi: >3.00E+3nMAssay Description:Binding affinity to androgen receptor by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2013
Entry Details Article
PubMed