BDBM50347388 CHEMBL1234833

SMILES CC(C)c1cnn2c(NCc3ccccc3)cc(N[C@@H](CO)[C@H](O)CO)nc12

InChI Key InChIKey=KRIWIRSMQRQYJG-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50347388   

TargetMitogen-activated protein kinase 1(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 3.11E+3nMAssay Description:Inhibition of ERK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CDK2 expressed in baculovirus infected Sf9 cells using Histone H1 as substrate incubated for 10 mins by scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 250nMAssay Description:Competitive reversible inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 30nMAssay Description:Competitive reversible inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 3.55E+4nMAssay Description:Competitive reversible inhibition of CDK6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 2.00E+4nMAssay Description:Competitive reversible inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 90nMAssay Description:Competitive reversible inhibition of CDK8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Cairo University

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 3nMAssay Description:Competitive reversible inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetCasein kinase I isoform alpha(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of CK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 3(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 90nMAssay Description:Inhibition of CDK9/cyclinT assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of DYRK1AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetInsulin receptor-related protein(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of IRRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 15(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 330nMAssay Description:Inhibition of ERK8More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 33nMAssay Description:Inhibition of CDK1/cyclinB1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2/cyclinE assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCalcium/calmodulin-dependent protein kinase kinase 2(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of CAMKKbetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibition of CDK6/cyclinD1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CDK4/cyclinD1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
Imperial College

Curated by ChEMBL
LigandPNGBDBM50347388(CHEMBL1234833)
Affinity DataIC50: 250nMAssay Description:Inhibition of CDK7/cyclinH/MAT1 assessed as amount of ATP released by luciferase activity based PKLight assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed