BDBM50346552 CHEMBL1797936

SMILES Cc1cc(-c2ccc(C=c3c(=C)[nH]n(-c4ccc(cc4)C(O)=O)c3=O)o2)c(cc1C)[N+]([O-])=O

InChI Key InChIKey=QZBUMRNGAHPCMI-UHFFFAOYSA-N

Data  4 KI  27 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 50346552   

TargetHistone acetyltransferase KAT5(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 3.72E+4nMAssay Description:Inhibition of GST tagged human TIP60 expressed in Sf9 cells using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLIS...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT7(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of recombinant human full length KAT7 using histone H3 peptide and [3H]-acetyl-coA as substrates incubated for 1 hrs by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT6B(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of recombinant human KAT6B (657 to 1069 residues) using histone H4 peptide and [3H]-acetyl-coA as substrates incubated for 1 hrs by liquid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT6A [507-778](Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human KAT6A (488 to 778 residues) using histone H3 peptide and [3H]-acetyl-coA as substrates incubated for 1 hrs by liquid ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT5(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 1.83E+4nMAssay Description:Inhibition of recombinant human full length KAT5 using histone H2A peptide and [3H]-acetyl-coA as substrates incubated for 1 hrs by liquid scintillat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 191nMAssay Description:Inhibition of recombinant human KAT3B (1287 to 1673 residues) using histone H3 peptide and [3H]-acetyl-coA as substrates incubated for 1 hrs by liqui...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant KDAC6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant KDAC3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant KDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of KAT3B HAT domain (1287 to 1652 residues) (unknown origin) expressed in Escherichia coli BL21(RIL)-DE3 using histone H4-15 peptide and 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase KAT2A(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 4.74E+4nMAssay Description:Inhibition of GST tagged human GCN5 (323 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 3.89E+4nMAssay Description:Inhibition of GST tagged human PCAF (431 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT6B(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of MYST4 (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase KAT7(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 7.81E+3nMAssay Description:Inhibition of MYST2 (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of synthetic VMA-tagged p300 (1287 to 1652 residues) (unknown origin) expressed in Escherichia coli BL21(RIL)-DE3 cells using H4-15 peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CBP (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of p300 HAT domain (unknown origin) using histone H4-15 peptide and acetyl-coA as substrates preincubated for 10 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EP300 (unknown origin) by AlphaLISA immunodetection assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of VMA intein chitin binding domain-fused P300 (unknown origin) (1287 to 1652 residues) expressed in Escherichia coli BL21(RIL)-DE3 cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 400nMAssay Description:Inhibition of p300 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 230nMAssay Description:Inhibition of p300 (unknown origin) using biotinylated histone H3 (1 to 21 residues) as substrate measured after 90 mins in presence of Acetyl CoA by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant P300 (1195 to 1662 residues) (unknown origin) using FITC-histone H4 as substrate incubated for 10 mins by microfluidic elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant P300 (1195 to 1662 residues) (unknown origin) using FITC-histone H4 as substrate incubated for 10 mins by microfluidic elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 5.10E+4nMAssay Description:Inhibition of recombinant P300 (1195 to 1662 residues) (unknown origin) using FITC-histone H4 as substrate incubated for 10 mins by microfluidic elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of recombinant P300 (1195 to 1662 residues) (unknown origin) using FITC-histone H4 as substrate incubated for 10 mins by microfluidic elec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of recombinant P300 catalytic domain (1284 to 1673 residues) (unknown origin) using FITC- histone H4 peptide (1 to 19 residues) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of FLAG-tagged p300 (1195 to 1673 residues) (unknown origin) expressed in competent Escherichia coli BL21-CodonPlus(DE3)-RIL cells using h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of p300 HAT domain (unknown origin) using varying concentrations of acetyl-CoA and constant concentration of H4-15 as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataKi:  400nMAssay Description:Inhibition of recombinant human KAT3B HAT domain (1287 to 1673 residues) expressed in Escherichia coli using histone H3 peptide and [Acetyl-3H]-acety...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataKi:  400nMAssay Description:Competitive inhibition of p300 HATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetHistone acetyltransferase p300(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50346552(CHEMBL1797936)
Affinity DataKi:  400nMAssay Description:Inhibition of synthetic VMA-tagged p300 (1287 to 1652 residues) (unknown origin) expressed in Escherichia coli BL21(RIL)-DE3 cells using H4-15 peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2017
Entry Details Article
PubMed