BDBM50346335 CHEMBL1782241::Cochinchinone A

SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-c1c(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c(-[#8])c2c1oc1ccc(-[#8])cc1c2=O

InChI Key InChIKey=HPUFSQMLYDASFT-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50346335   

TargetTranscription factor p65(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50346335(Cochinchinone A | CHEMBL1782241)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NFkappa p65 in nuclear extract of human HeLa cells assessed as blockade of NFkappa p65 binding to biotinylated-consesus sequence by ELI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetProbable maltase-glucoamylase 2(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50346335(Cochinchinone A | CHEMBL1782241)
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) using PNP-G as substrate measured for 15 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50346335(Cochinchinone A | CHEMBL1782241)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using P-NPP as substrate after 10 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50346335(Cochinchinone A | CHEMBL1782241)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of recombinant human PTP1B (1 to 322 residues) expressed in Escherichia coli using P-NPP as substrate after 10 mins by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetProbable maltase-glucoamylase 2(Human)
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50346335(Cochinchinone A | CHEMBL1782241)
Affinity DataKi:  1.34E+4nMAssay Description:Inhibition of alpha-glucosidase (unknown origin) using PNP-G as substrate by Dixon plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed