BDBM50346313 CHEMBL1782579::cis-((1S,3R)-1-isopropyl-3-(tetrahydro-2H-pyran-4-ylamino)cyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone

SMILES CC(C)[C@@]1(CC[C@H](C1)NC1CCOCC1)C(=O)N1CCN(CC1)c1cc(ccn1)C(F)(F)F

InChI Key InChIKey=CFFHQGYBIQAXID-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50346313   

TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346313(cis-((1S,3R)-1-isopropyl-3-(tetrahydro-2H-pyran-4-...)
Affinity DataIC50: 19.7nMAssay Description:Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346313(cis-((1S,3R)-1-isopropyl-3-(tetrahydro-2H-pyran-4-...)
Affinity DataIC50: 101nMAssay Description:Antagonist activity at human CCR2 by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed