BDBM50346310 CHEMBL1782376::cis-((1S,3R)-3-(3-oxabicyclo[3.3.1]nonan-9-ylamino)-1-isopropylcyclopentyl)(4-(4-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)methanone

SMILES CC(C)[C@@]1(CC[C@H](C1)NC1C2CCCC1COC2)C(=O)N1CCN(CC1)c1cc(ccn1)C(F)(F)F

InChI Key InChIKey=FVSIYTJTQCCANT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50346310   

LigandPNGBDBM50346310(cis-((1S,3R)-3-(3-oxabicyclo[3.3.1]nonan-9-ylamino...)
Affinity DataIC50: 1.20E+3nMAssay Description:Displacement of labeled dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50346310(cis-((1S,3R)-3-(3-oxabicyclo[3.3.1]nonan-9-ylamino...)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of labeled dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346310(cis-((1S,3R)-3-(3-oxabicyclo[3.3.1]nonan-9-ylamino...)
Affinity DataIC50: 7.30nMAssay Description:Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346310(cis-((1S,3R)-3-(3-oxabicyclo[3.3.1]nonan-9-ylamino...)
Affinity DataIC50: 11.2nMAssay Description:Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346310(cis-((1S,3R)-3-(3-oxabicyclo[3.3.1]nonan-9-ylamino...)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at human CCR2 by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346310(cis-((1S,3R)-3-(3-oxabicyclo[3.3.1]nonan-9-ylamino...)
Affinity DataIC50: 65nMAssay Description:Antagonist activity at human CCR2 by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed