BDBM50346296 CHEMBL1782378::cis-((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl)(methyl)amino)cyclopentyl)(4-(5-(trifluoromethyl)pyridazin-3-yl)piperazin-1-yl)methanone

SMILES CO[C@@H]1COCC[C@@H]1N(C)[C@@H]1CC[C@](C1)(C(C)C)C(=O)N1CCN(CC1)c1cc(cnn1)C(F)(F)F

InChI Key InChIKey=MRJZQHBWCLENCQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50346296   

TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346296(cis-((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetr...)
Affinity DataIC50: 73.9nMAssay Description:Antagonist activity at human CCR2 by whole blood assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
LigandPNGBDBM50346296(cis-((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetr...)
Affinity DataIC50: 5.28E+4nMAssay Description:Displacement of labeled dofetilide from human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50346296(cis-((1S,3R)-1-isopropyl-3-(((3S,4S)-3-methoxytetr...)
Affinity DataIC50: 31.9nMAssay Description:Displacement of [125I]MCP1 from human CCR2 preincubated for 30 mins by human whole cell binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed