BDBM50346123 2-(4-(5-ethyl-2-(5-fluorothiophen-2-yl)-6-methylpyrimidin-4-ylamino)-3-fluorophenyl)acetic acid::CHEMBL1782308

SMILES CCc1c(C)nc(nc1Nc1ccc(CC(O)=O)cc1F)-c1ccc(F)s1

InChI Key InChIKey=CXBHAEGCPVKQMW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50346123   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50346123(2-(4-(5-ethyl-2-(5-fluorothiophen-2-yl)-6-methylpy...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human PDE4B1 incubated for 10 mins using cAMP and [3H]cAMP substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50346123(2-(4-(5-ethyl-2-(5-fluorothiophen-2-yl)-6-methylpy...)
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human PDE4D3 incubated for 10 mins using cAMP and [3H]cAMP substratesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50346123(2-(4-(5-ethyl-2-(5-fluorothiophen-2-yl)-6-methylpy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50346123(2-(4-(5-ethyl-2-(5-fluorothiophen-2-yl)-6-methylpy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50346123(2-(4-(5-ethyl-2-(5-fluorothiophen-2-yl)-6-methylpy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Asahi Kasei Pharma

Curated by ChEMBL
LigandPNGBDBM50346123(2-(4-(5-ethyl-2-(5-fluorothiophen-2-yl)-6-methylpy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed