BDBM50346073 CHEMBL1783985::cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone

SMILES O=C(C1CCC1)N1CCCC2(CCCCC2)C1

InChI Key InChIKey=FKNJDTXOOMHZMJ-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50346073   

TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataIC50: 820nMAssay Description:Non-competitive antagonist activity at mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 8(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR8More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 7(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of mGluR7More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50346073(cyclobutyl(2-azaspiro[5.5]undecan-2-yl)methanone |...)
Affinity DataKi:  840nMAssay Description:Displacement of [3H]3-methoxy-5-(2-pyridinylethynyl) pyridine from mGluR5 allosteric siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed