BDBM50345919 9-Prop-2-ynylamino-3-p-tolyl-3H-thieno[2,3-d:4,5-d']dipyrimidin-4-one::CHEMBL1784068

SMILES Cc1ccc(cc1)-n1cnc2c(sc3ncnc(NCC#C)c23)c1=O

InChI Key InChIKey=YLSUDQILVFXJBQ-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50345919   

TargetMetabotropic glutamate receptor 1(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50345919(9-Prop-2-ynylamino-3-p-tolyl-3H-thieno[2,3-d:4,5-d...)
Affinity DataIC50: 3.90nMAssay Description:Antagonist activity at human mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50345919(9-Prop-2-ynylamino-3-p-tolyl-3H-thieno[2,3-d:4,5-d...)
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonist activity at human mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50345919(9-Prop-2-ynylamino-3-p-tolyl-3H-thieno[2,3-d:4,5-d...)
Affinity DataKi:  8.30nMAssay Description:Antagonist activity at rat mGluR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed