BDBM50345705 1-(1-methylethyl)-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::1-isopropyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine::CHEMBL1231370::CHEMBL2069954::US10544104, Compound 3::US11247972, Compound 3::US9765037, Compound 3
SMILES CC(C)n1c2c(c(n1)Cc3cccc4c3cccc4)c(ncn2)N
InChI Key InChIKey=QFGDRGRJMYSRIW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50345705
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For
US Patent
University of Washington Through Its Center For
US Patent
Affinity DataIC50: 147nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
3D Structure (crystal)TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 147nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetcGMP-dependent protein kinase(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 128nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 8.80E+3nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 7.90E+3nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
TargetcGMP-dependent protein kinase(Toxoplasma gondii)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 130nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
TargetCalcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 150nMAssay Description:Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of Toxoplasma gondii recombinant N-terminal hexahistidine tagged CDPK1 expressed in Escherichia coli using syntide-2 as substrate after 90...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 128nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 103nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1, putative(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For
US Patent
University of Washington Through Its Center For
US Patent
Affinity DataIC50: 150nMAssay Description:Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...More data for this Ligand-Target Pair
TargetCalcium-dependent protein kinase 1(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 147nMAssay Description:Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...More data for this Ligand-Target Pair
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington
Curated by ChEMBL
University of Washington
Curated by ChEMBL
Affinity DataIC50: 128nMAssay Description:Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...More data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Human)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human tyrosine kinases.More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington Through Its Center For Commercialization
US Patent
University of Washington Through Its Center For Commercialization
US Patent
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphor imaging methodMore data for this Ligand-Target Pair