BDBM50345537 CHEMBL1784369::N-(4-((4-(4-chloro-2-methylphenethyl)piperidin-1-ylsulfonyl)methyl)-1-(cyclobutanecarbonyl)piperidin-4-yl)-N-hydroxyformamide::US10322143, Compound 15c

SMILES Cc1cc(Cl)ccc1CCC1CCN(CC1)S(=O)(=O)CC1(CCN(CC1)C(=O)C1CCC1)N(O)C=O

InChI Key InChIKey=SIXCEPSXNLUZTE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50345537   

LigandPNGBDBM50345537(N-(4-((4-(4-chloro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 20nMAssay Description:Inhibition of ADAMTS-5 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345537(N-(4-((4-(4-chloro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ADAMTS-4 assessed as substrate cleavage after 16 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
LigandPNGBDBM50345537(N-(4-((4-(4-chloro-2-methylphenethyl)piperidin-1-y...)
Affinity DataIC50: 1.20nMAssay Description:Protein concentrations were measured using the Micro BCA Protein Assay Kit (Pierce/Thermo Scientific, IL). Sample buffer was mixed with 5-25 μg ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/10/2020
Entry Details
Go to US Patent