BDBM50345444 CHEMBL1784725::Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxylate

SMILES CCOC(=O)c1c2c3cccc4cccc(c2nc1=O)c34

InChI Key InChIKey=CEEHIKQKZBQZLL-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50345444   

TargetMast/stem cell growth factor receptor Kit(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-kit expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Met expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphB2 expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetEphrin type-A receptor 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EphA2 expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Abl using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Src expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR2 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetMacrophage-stimulating protein receptor(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RON expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRbeta using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFRalpha using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2 expressed in Bac-to-Bac Baculovirus expression system using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of VEGFR1 using poly(Glu-Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR4 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of FGFR3 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR2 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50345444(Ethyl 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carboxyl...)
Affinity DataIC50: 74nMAssay Description:Inhibition of FGFR1 using poly(Glu-Tyr)4:1 as substrate after 60 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed