BDBM50345437 6-ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine::CHEMBL1784714::US9238653, Table 5, Compound 8

SMILES CCc1c(C)nc2ncnn2c1Nc1ccc(cc1)C(C)C

InChI Key InChIKey=HSKDDEMAAZUZGH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50345437   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University Of Texas

US Patent
LigandPNGBDBM50345437(6-ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]tria...)
Affinity DataIC50: 1.66E+3nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. falciparum)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50345437(6-ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]tria...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of His6-tagged recombinant Plasmodium falciparum dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50345437(6-ethyl-N-(4-isopropylphenyl)-5-methyl-[1,2,4]tria...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of His6-tagged recombinant human dihydroorotate dehydrogenase expressed in Escherichia coli using L-dihydroorotate as substrate after 10 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed