BDBM50345312 CHEMBL1784198::Ethyl 5-cyano-6-{4-[(2-naphthylamino)carbonyl]piperazin-1-yl}-2-(trifluoromethyl)-nicotinate

SMILES CCOC(=O)c1cc(C#N)c(nc1C(F)(F)F)N1CCN(CC1)C(=O)Nc1ccc2ccccc2c1

InChI Key InChIKey=YLHXUNCMWADQFJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345312   

TargetP2Y purinoceptor 12(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50345312(Ethyl 5-cyano-6-{4-[(2-naphthylamino)carbonyl]pipe...)
Affinity DataIC50: 83nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50345312(Ethyl 5-cyano-6-{4-[(2-naphthylamino)carbonyl]pipe...)
Affinity DataIC50: 190nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed