BDBM50345306 CHEMBL1784193::Ethyl 6-(4-{[(4-chlorophenyl)amino]carbonyl}piperazin-1-yl)-5-cyano-2-(trifluoro-methyl)nicotinate

SMILES CCOC(=O)c1cc(C#N)c(nc1C(F)(F)F)N1CCN(CC1)C(=O)Nc1ccc(Cl)cc1

InChI Key InChIKey=IJMCFIRGRAKECE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345306   

TargetP2Y purinoceptor 12(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50345306(Ethyl 6-(4-{[(4-chlorophenyl)amino]carbonyl}pipera...)
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50345306(Ethyl 6-(4-{[(4-chlorophenyl)amino]carbonyl}pipera...)
Affinity DataIC50: 310nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed