BDBM50345303 CHEMBL1784190::Ethyl 5-cyano-6-(4-{[(3-methylphenyl)amino]carbonyl}piperazin-1-yl)-2-(trifluoro-methyl)nicotinate

SMILES CCOC(=O)c1cc(C#N)c(nc1C(F)(F)F)N1CCN(CC1)C(=O)Nc1cccc(C)c1

InChI Key InChIKey=KWEGADIBCIXHAT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50345303   

TargetP2Y purinoceptor 12(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50345303(Ethyl 5-cyano-6-(4-{[(3-methylphenyl)amino]carbony...)
Affinity DataIC50: 180nMAssay Description:Antagonist activity at human recombinant P2Y12 receptor expressed in platelet cell membrane by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetP2Y purinoceptor 12(Human)
Astrazeneca R&D

Curated by ChEMBL
LigandPNGBDBM50345303(Ethyl 5-cyano-6-(4-{[(3-methylphenyl)amino]carbony...)
Affinity DataIC50: 210nMAssay Description:Displacement of [125I]-AZ11931285 from human recombinant P2Y12 receptor expressed in platelet cell membrane after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed