BDBM50344435 CHEMBL1779999::trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro-[[2]benzopyran-1,1'-cyclohexan]-4'-amine

SMILES COC1Cc2ccccc2[C@@]2(CC[C@@H](CC2)N(C)Cc2ccccc2)O1

InChI Key InChIKey=AFKWCRVKGFPGQY-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50344435   

TargetMu-type opioid receptor(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50344435(trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro...)
Affinity DataKi:  18nMAssay Description:Binding affinity to human mu opioid receptor by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50344435(trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro...)
Affinity DataKi:  40nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in human RPMI8226 cell membranes incubated for 2 hrs under shaking by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50344435(trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in guinea pig brain membranes after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50344435(trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain by scintillation analyzerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50344435(trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro...)
Affinity DataKi:  43nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain cortex membranes after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50344435(trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro...)
Affinity DataKi:  250nMAssay Description:Displacement of [3H]U69,593 from kappa opioid receptor in guinea pig brain membrane after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50344435(trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro...)
Affinity DataKi:  371nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in rat membranes after 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Universit£T M£Nster

Curated by ChEMBL
LigandPNGBDBM50344435(trans-N-Benzyl-3-methoxy-N-methyl-3,4-dihydrospiro...)
Affinity DataKi:  1.44E+3nMAssay Description:Displacement of [3H]-di-o-tolylguanidine from sigma2 receptor in rat liver membranes incubated for 120 mins in the presence of sigma1 receptor ligand...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed