BDBM50344417 6-Methyl-2-phenylethynyl-7,8-dihydro-6H-1,6-naphthyridin-5-one::CHEMBL1779847

SMILES CN1CCc2nc(ccc2C1=O)C#Cc1ccccc1

InChI Key InChIKey=BSIQTYGSKNJGGV-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344417   

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344417(6-Methyl-2-phenylethynyl-7,8-dihydro-6H-1,6-naphth...)
Affinity DataIC50: 30nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344417(6-Methyl-2-phenylethynyl-7,8-dihydro-6H-1,6-naphth...)
Affinity DataKi:  760nMAssay Description:Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed