BDBM50344414 CHEMBL1779846::N-cyclopentyl-6-(pyridin-3-ylethynyl)nicotinamide

SMILES O=C(NC1CCCC1)c1ccc(nc1)C#Cc1cccnc1

InChI Key InChIKey=YYCJVMDCFGFZEP-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344414   

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344414(N-cyclopentyl-6-(pyridin-3-ylethynyl)nicotinamide ...)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as increase of L-glutamate-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344414(N-cyclopentyl-6-(pyridin-3-ylethynyl)nicotinamide ...)
Affinity DataKi: >3.20E+4nMAssay Description:Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed