BDBM50344402 2-((4-chlorophenyl)ethynyl)-6-cyclopentyl-7,8-dihydro-1,6-naphthyridin-5(6H)-one::CHEMBL1779875

SMILES Clc1ccc(cc1)C#Cc1ccc2C(=O)N(CCc2n1)C1CCCC1

InChI Key InChIKey=GLULGXMHQKVTOE-UHFFFAOYSA-N

Data  1 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344402   

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344402(2-((4-chlorophenyl)ethynyl)-6-cyclopentyl-7,8-dihy...)
Affinity DataEC50:  979nMAssay Description:Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as increase of L-glutamate-induced calcium mobilization by FLIPR as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344402(2-((4-chlorophenyl)ethynyl)-6-cyclopentyl-7,8-dihy...)
Affinity DataKi: >3.20E+4nMAssay Description:Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed