BDBM50344390 6-isopropyl-2-((3-methoxyphenyl)ethynyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one::CHEMBL1779865

SMILES COc1cccc(c1)C#Cc1ccc2C(=O)N(CCc2n1)C(C)C

InChI Key InChIKey=YMWZFVRRHGUOLL-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50344390   

TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344390(6-isopropyl-2-((3-methoxyphenyl)ethynyl)-7,8-dihyd...)
Affinity DataIC50: 111nMAssay Description:Negative allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as inhibition of L-glutamate-induced calcium mobilization by FLIPR ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50344390(6-isopropyl-2-((3-methoxyphenyl)ethynyl)-7,8-dihyd...)
Affinity DataKi:  2.95E+3nMAssay Description:Displacement of [3H]-MPEP from human mGluR5 expressed in HEK293 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed