BDBM503443 4-Chloro-5-(4-(difluoromethoxy)-6-((S*)-3,3,3-trifluoro-2-methylpropyl)pyridin-3-yl)-1-ethyl-N-(((1s,4R)-1-hydroxy-4-(methylsulfonyl)cyclohexyl)methyl)-1H-pyrazole-3-carboxamide::US11034658, Example 15

SMILES CCn1nc(C(=O)NC[C@@]2(O)CC[C@H](C)CC2)c(Cl)c1-c1cnc(C[C@H](C)C(F)(F)F)cc1OC(F)F

InChI Key InChIKey=PKKBHTGIGOXUEF-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 503443   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM503443(4-Chloro-5-(4-(difluoromethoxy)-6-((S*)-3,3,3-trif...)
Affinity DataKd:  12nMAssay Description:ThermoFluor is a fluorescence based assay that estimates ligand binding affinities by measuring the effect of a ligand on protein thermal stability (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent