BDBM50344086 CHEMBL1777878::cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluoromethyl)phenoxy)phenyl)but-2-ynyl)oxazolidine-2,4-dione

SMILES CC#C[C@H](c1oc(=O)[nH]c1O)c1ccc(Oc2ccc(cc2OC(F)F)C(F)(F)F)cc1

InChI Key InChIKey=BYYGRGHKBACQED-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50344086   

TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of Cav1.2 calcium channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataEC50:  136nMAssay Description:Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataIC50: 151nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344086(cis-rac-5-(1-(4-(2-(difluoromethoxy)-4-(trifluorom...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed