BDBM50344075 CHEMBL1777868::rac-3-(4-(3-cyanopyrazin-2-yloxy)phenyl)hex-4-ynoic acid

SMILES CC#CC(CC(O)=O)c1ccc(Oc2nccnc2C#N)cc1

InChI Key InChIKey=QPIICQXBXFBNLV-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50344075   

TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344075(rac-3-(4-(3-cyanopyrazin-2-yloxy)phenyl)hex-4-ynoi...)
Affinity DataEC50:  1.58E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344075(rac-3-(4-(3-cyanopyrazin-2-yloxy)phenyl)hex-4-ynoi...)
Affinity DataEC50:  985nMAssay Description:Agonist activity at mouse GPR40 expressed in CHO cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344075(rac-3-(4-(3-cyanopyrazin-2-yloxy)phenyl)hex-4-ynoi...)
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of human GPR40 expressed in CHO cells by SPA based binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2011
Entry Details Article
PubMed